Glossary terms - O orexigenic Orexigenic agents are appetite stimulants. These can be endogenous hormones (e.g. ghrelin, orexin or neuropeptide Y) or agents administered as drugs; tricyclic antidepressants (TCAs), natural or synthetic cannabinoids, some first-generation antihistamines, and many antipsychotics and steroid hormones all act as orexigenics. This article was published on 2025-01-28